My wife plays The Sims a lot, so I have a good idea of how mean the gods of simulation games are to their creations and subjects. People get left to drown in pools, while others get locked in a basement, their sole purpose in life to make artworks to be sold by the rest of the family, who live in decadence upstairs.
If you think that sounds like a mean thing to do to your little simulation people, then you need to watch this video by flawless128. He takes a nice happy city of 200,000 people in Cities: Skylines, and then decimates them with a tidal wave of their own poo. Yeah. What a nice guy. The sewage kills everyone, but at least if put the fires out, right?